A Trial of Mass Isoniazid Preventive Therapy for Tuberculosis Control

A Trial of Mass Isoniazid Preventive Therapy for Tuberculosis Control (pdf)
Gavin J. Churchyard, M.B., B.Ch., Ph.D., Katherine L. Fielding, Ph.D., James J. Lewis, Ph.D., Leonie Coetzee, D.Soc.Sc., Elizabeth L. Corbett, M.B., B.Chir., Ph.D., Peter Godfrey-Faussett, F.R.C.P., Richard J. Hayes, D.Sc., Richard E. Chaisson, M.D., and Alison D. Grant, M.B., B.S., Ph.D., for the Thibela TB Study Team

 

Fuente: N Engl J Med 370;4 nejm.org january 23, 2014

http://www.nejm.org/doi/pdf/10.1056/NEJMoa1214289

Background
Tuberculosis is epidemic among workers in South African gold mines. We evaluated an intervention to interrupt tuberculosis transmission by means of mass screening that was linked to treatment for active disease or latent infection.